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  Clinical Pharmacokinetics - The...

  Ava Westwood

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  Pharmacokinetics is a fundamental aspect of clinical medicine, shaping the way drugs are administered, absorbed, distributed, metabolized, and eliminated by the body. It provides a scientific basis for determining appropriate drug dosing, optimizing therapeutic efficacy, and minimizing adverse effects. Understanding pharmacokinetics allows healthcare professionals to make informed decisions tailored to individual patients, ensuring safe and effective drug therapy. 
  One of the most significant applications of pharmacokinetics in clinical practice is dose optimization. Drug concentration within the body must remain within a therapeutic window—high enough to produce the desired effect but not so high that it causes toxicity. By considering factors such as bioavailability, volume of distribution, and clearance, clinicians can determine the appropriate dosing regimen. This is particularly critical for drugs with a narrow therapeutic index, such as warfarin, lithium, and certain chemotherapeutic agents, where even small variations in plasma levels can lead to significant clinical consequences. 
  Pharmacokinetics also plays a crucial role in adjusting drug therapy for specific patient populations. Factors such as age, organ function, and genetic variability can influence how a drug is processed. In neonates and elderly patients, metabolic and renal clearance mechanisms are often reduced, requiring dose modifications to prevent accumulation and toxicity. Similarly, patients with renal or hepatic impairment need adjusted dosing regimens to account for altered drug metabolism and elimination. Advances in pharmacogenomics further refine this approach, allowing for individualized treatment based on genetic variations affecting drug-metabolizing enzymes.

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  Geometry - A Very Short...

  Maciej Dunajski

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  The study of geometry is at least 2500 years old, and it is within this field that the concept of mathematical proof—deductive reasoning from a set of axioms—first arose. To this day geometry remains a very active area of research in mathematics. 
   
   
   
  This Very Short Introduction covers the areas of mathematics falling under geometry, starting with topics such as Euclidean and non-Euclidean geometries, and ranging to curved spaces, projective geometry in Renaissance art, and geometry of space-time inside a black hole. Starting from the basics, Maciej Dunajski proceeds from concrete examples (of mathematical objects like Platonic solids, or theorems like the Pythagorean theorem) to general principles. Throughout, he outlines the role geometry plays in the broader context of science and art.

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  Design Dissected - Is the design...

  David Galloway

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  Many people assert that all of reality, including life, has simply emerged as a result of natural law and circumstance. How credible is that assumption? How well does it fit with what we find? Exquisite features of apparent design are in evidence everywhere we look. Either something is responsible for all the molecular engineering of life or, it just happened and nothing is directly responsible. Which option offers the best explanation? 
  This book provides a clinician’s perspective on the evidence for design in living things. Specific scenarios are dissected from examples of real cases in clinical medicine and surgery, as well as descriptions of some of the amazing integrated systems that exist in human physiology. Read about the critical processes that must be successfully navigated at the time of birth for every individual to have any prospect of survival. Beyond that, think about thinking itself. This book is a powerful challenge to the belief that the universe, life, and conscious experience can result only from unguided, natural processes.  
  “Excellent ... a most enjoyable mix of personal anecdote and scientific precision.”  Prof John C Lennox  
  “Fresh and original. Beautifully written and extensively researched. Highly recommended.”  Dr Stephen C. Meyer  
  “Impressive and thought provoking”  Prof Frank Dunn  
  For further information visit:  www.davidgalloway.co.uk  
  DAVID J GALLOWAY MD DSc FRCS FRCP FACS FACP  
  David Galloway is a Scottish surgeon who trained in Glasgow, London, and New York City. He was a Consultant Surgeon in Glasgow and a Former President of the Royal College of Physicians and Surgeons of Glasgow. He is also a Fellow of numerous international medical and surgical Colleges and has held academic appointments in Glasgow, Kuala Lumpur and Hong Kong. 

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  A Magical Night Journey

  Amy T Won

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  A beautifully illustrated guidebook to unleash the enchanted explorer in you and help you embark on a voyage through the night to find the wonder and wisdom of nature and creativity.
  Become the wonder-seeker you truly are as you explore the night. In this magical book, Amy T. Won, artist and guide, takes you on a personal creative night journey, exploring nocturnal wildlife and plants, twilight fairy tales and celestial myths, constellations and the cycles of the moon, and personal recollections of the night, such as camping or evening festivities. Amy's dreamy watercolour paintings of the enchanting night are interspersed with practical activities for the reader and fill-in pages to encourage you to record your experience. Through this exploration, connecting to your senses and examining your memories, you can learn your fears and hopes and develop your creativity to find inspiration. Capture the feeling of wonderment and creative flow, explore to your heart's delight and experience the magic-making. Allow the world around you to whisper in your ears what you wish most to create.

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  The Security Culture Playbook -...

  Kai Roer, Perry Carpenter

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  The topic of security culture is mysterious and confusing to most leaders. But it doesn't have to be. In The Security Culture Playbook, Perry Carpenter and Kai Roer deliver experience-driven, actionable insights into how to transform your organization's security culture and reduce human risk at every level. This book exposes the gaps between how organizations have traditionally approached human risk and it provides security and business executives with the necessary information and tools needed to understand, measure, and improve facets of security culture across the organization. 
   
   
   
  The book offers: an exposé of what security culture really is and how it can be measured; a careful exploration of the seven dimensions that comprise security culture; practical tools for managing your security culture program, such as the Security Culture Framework and the Security Culture Maturity Model; and insights into building support within the executive team and Board of Directors for your culture management program. 
   
   
   
  Also including several revealing interviews from security culture thought leaders in a variety of industries, The Security Culture Playbook is an essential resource for cybersecurity professionals, risk and compliance managers, executives, board members, and other business leaders seeking to proactively manage and reduce risk.

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  Ultimate AWS Certified Cloud...

  Gaurav H Kankaria

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  Empowering Your Journey to a Successful AWS Cloud Certification
  Book Description
  Embark on a journey into AWS cloud computing certification with the "Ultimate AWS Certified Cloud Practitioner’s Exam Guide"
  This book is your ultimate guide to mastering AWS CLF-C02 certification by simplifying cloud computing basics and giving you a strong grasp of its core principles and benefits.
  The book simplifies AWS services like EC2, S3, and RDS, with clear explanations and real-world examples. You'll master these services and learn industry best practices for cost optimization, security, and compliance, ensuring your deployments are efficient and secure. Additionally, it empowers you to navigate the ever-changing world of cloud computing with confidence.
  With exam readiness at the forefront, the book provides a meticulous preparation plan, complete with practice questions, exam strategies, and hands-on exercises to fortify your knowledge and boost your confidence. Whether you're gearing up for the AWS Cloud Practitioner exam or seeking to enhance your professional skill set, the practical approach ensures you're primed for success.
  Table of Contents
  1. Introduction to AWS Cloud Practitioner Exam (CLF - C02)
  2. Understanding Cloud Computing
  3. Introduction to AWS and Global Infrastructure
  4. AWS Well-Architected Framework and Shared Responsibility Model
  5. AWS Core Services – Part I
  6. AWS Core Services – Part II
  7. AWS Core Services – Part III
  8. Other AWS Services
  9. Billing and Pricing
  10. Preparing for Exam
  11. AWS Hands-on Guide for Beginners   
  Index

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