Altri libri che potrebbero interessarti

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  The Impact of Off-Label...

  Vanessa Plate

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  In times of situational therapeutic impasse, health care professionals (HCPs) are under pressure to conduct off-label, unlicensed and compassionate drug use – generally summarized under the term non-licensed drug use (NDU). Liability, contractual and penal risks pose a problem when treating a patient in a non-licensed way. There is a knowledge gap about institutional and governmental methods to resolve these problems. Different countries have developed strategies to manage NDU.  In her book, Vanessa Platé compares the effects of NDU on pharmaceutical legislation in selected industrial countries and determines strategies brought forth by NDU. Furthermore, the development of a general regulatory approach to the management of NDU is sought.  Semi-structured qualitative interviews, comparison of laws, and literature research are part of this study, which includes Canada, the U.S., the U.K., Japan, France, Germany, Switzerland, Austria, and the transnational E.U. The comparison of the impact of NDU focuses on terminology for NDU, supply and necessity of NDU, pharmaceutical promotion of NDU, legal responsibility for NDU, and public policies related to NDU.  The results of the study suggest there is indeed a circumstantial need for off-label, unlicensed and compassionate use, but also showed isolated evidence suggesting intermittent non-rational NDU. Furthermore, the legal comparison showed evidence of legal obligations for physicians to perform off-label, unlicensed and compassionate drug use. Vanessa Platé also found proof of inappropriate off-label marketing on the part of market authorization holders (MAH). On the other hand, a demand for information on NDU on behalf of HCPs was present. Obtained results illustrate cross-liability for HCPs and MAH. Finally, results demonstrated regulatory strategies of different efficiencies: In the E.U., for instance, incentives for new indications were (a) limited to one year or (b) restricted to (i) pediatrics or (ii) rare disorders.  The absence of statutory terminology causes incoherent interpretation of NDU across the researched nations; harmonization is crucial for an effective concept development. There is a situational need for early access to yet unapproved treatments. Denial of (non-licensed) treatment is considered unethical. Proposed solutions for an enduring management of NDU are firstly the amendments of templates for patient information leaflets by competent authorities to include well-recognised off-label use, secondly full development, research and duly authorized marketing of medicinal products used compassionately, and thirdly, modelled on German procedure, a modified standard market authorization for essential unlicensed drugs.

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  The Monarch Butterfly Migration...

  Monika Maeckle

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  Each fall, millions of monarch butterflies migrate from Canada to Mexico. The monarch migration is a demonstration of nature's ingenuity, but the delicate creatures face many perils, and the number of migrating monarchs is declining sharply. This book weaves natural history, science, and personal experience to explore the rise and fall of one of nature's most spectacular phenomena. 
   
   
   
  While monarch butterflies have been migrating for centuries, they seized public attention in 1976 when a National Geographic magazine cover story featured the "discovery" of their roosting sites in Mexico. The revelations put a spotlight on the insects and inspired the creation of butterfly sanctuaries in Mexico as well as efforts to protect them. Almost forty years later, many believe that monarch butterflies are in danger of extinction. Journalist and butterfly advocate Monika Maeckle delves into the rich history and current plight of the monarch butterfly. Maeckle offers unique insights on the butterflies as well as a nuanced portrait of the community of scientists, enthusiasts, and "flutterati" who have emerged to support the monarchs. 
   
   
   
  The Monarch Butterfly Migration focuses a wider lens on the effects of climate change and the tensions between advocacy and scientific accuracy. This book reminds us to notice the natural wonders in our own backyards.

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  Climate Restoration - The Only...

  Peter Fiekowsky, Carole Douglis

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  The Paris Accords, widely accepted as the key to solving today's climate crisis, set a goal of zero net carbon emissions by 2050. But that's not good enough. The only way to guarantee a livable future is climate restoration, which can reduce greenhouse gases to historic levels. Scientist and entrepreneur Peter Fiekowsky explains the technology and maps a practical path that will let humankind survive and thrive. 
   
   
   
  As Fiekowsky explains in Climate Restoration, this will require removing a trillion tons of excess CO2 from the atmosphere. The good news is that this task, while enormous and technically challenging, is eminently feasible. Scientists and engineers have developed four major technologies for greenhouse gas removal and storage: ocean iron fertilization; synthetic limestone manufacture; seaweed permaculture; and methane oxidation. 
   
   
   
  Fiekowsky shows that these technologies are safe and practical—and, even more remarkable, that they require little if any government funding, since they can be financed largely through existing markets. For these reasons, they have enormous promise as vehicles for achieving climate restoration. With the global climate crisis continuing to spiral out of control, the time for tough conversations about what it will really take to create a healthy future for humanity is here.

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  The Elegant Universe

  PhD Brian Thomas Swimme, Thomas...

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  Most of us fail to appreciate the order of magnitude of the changes happening right now on our own planet. Swimme and Berry place current events in their larger context, to illustrate how we may be entering an unprecedented planetary age.

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  Kaizen - The Lifelong Journey of...

  Steve Abrams

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  Embark on a transformative journey with "Kaizen: The Lifelong Journey of Continuous Improvement," a comprehensive guide to integrating the powerful philosophy of Kaizen into both your professional and personal life. Originating in post-WWII Japanese manufacturing, Kaizen — which means "continuous improvement" — has evolved into a global symbol of efficiency, quality, and innovation. 
  This enlightening book delves into the roots and evolution of the Kaizen philosophy, providing readers with a thorough understanding of its principles and practices. From the essential "Five Ss" to the sophisticated integration of systems that support ongoing progress, the book offers a deep dive into the mechanisms that drive successful implementation. 
  Through a mix of historical context, influential figures, and transformative principles, each chapter unfolds the layered significance of Kaizen. Real-world examples across various sectors including healthcare, education, and technology illustrate Kaizen's versatile applications and demonstrate its potential to enhance not just workplace efficiency but also personal growth and productivity. 
  "Kaizen: The Lifelong Journey of Continuous Improvement" is not just theoretical but intensely practical, equipped with a variety of tools and techniques to help you implement Kaizen in your daily routines and organizational practices. Beyond the fundamentals, the book explores how to cultivate a culture of continuous improvement through strategic leadership and proactive employee engagement. 
  Step into a world of ongoing betterment, where every small change contributes to a grand transformation. "Kaizen: The Lifelong Journey of Continuous Improvement" is your guide to living a life marked by perpetual growth and enduring success. 
   

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  Making Mental Might - How to...

  Bernard Patten

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  Doctor Bernard Patten―erstwhile Memory Fellow of the New York Academy of Medicine, founder of the first memory clinic at the Neurological Institute of New York, and author of scientific papers on memory therapy and memory problems―wants to help you to a better mind, a better memory, and, consequently, a better life. 
  Memory degradation happens to everyone. Even people in good health forget where they park their cars or leave their reading glasses. Some draw a blank entering their PIN. Is the stove off? Cat fed? Door locked? Did you take your medication? Not sure? How come? These memory problems only get worse as we get older unless we employ mental exercises to improve memory now. 
  Mountains of scientific research prove that mental exercise benefits the brain as much as physical exercise benefits the body. Mental gymnastics boosts brainpower, augments memory, and (in some cases) actually increases brain size. It can help prevent dementia, mental decline, and the much-feared Alzheimer's disease. 
  Making Mental Might does not aim to increase your IQ or show you how to get smarter. It offers the proper mental training to look, sound, and perform worlds better. These techniques have helped hundreds of students at Rice University's School of Continuing Studies under Doctor Patten improve their working memory. They can do the same for you.

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