Join us on a literary world trip!
Add this book to bookshelf
Grey
Write a new comment Default profile 50px
Grey
Subscribe to read the full book or read the first pages for free!
All characters reduced
Life Histories of Genetic Disease - Patterns and Prevention in Postwar Medical Genetics - cover

Life Histories of Genetic Disease - Patterns and Prevention in Postwar Medical Genetics

Andrew J. Hogan

Publisher: Johns Hopkins University Press

  • 0
  • 0
  • 0

Summary

A richly detailed history that “uncovers the challenges and limitations of our increasing reliance on genetic data in medical decision making” (Shobita Parthasarathy, author of Building Genetic Medicine). 
 
Medical geneticists began mapping the chromosomal infrastructure piece by piece in the 1970s by focusing on what was known about individual genetic disorders. Five decades later, their infrastructure had become an edifice for prevention, allowing expectant parents to test prenatally for hundreds of disease-specific mutations using powerful genetic testing platforms. In this book, Andrew J. Hogan explores how various diseases were “made genetic” after 1960, with the long-term aim of treating and curing them using gene therapy. In the process, he explains, these disorders were located in the human genome and became targets for prenatal prevention, while the ongoing promise of gene therapy remained on the distant horizon. 
 
In narrating the history of research that contributed to diagnostic genetic medicine, Hogan describes the expanding scope of prenatal diagnosis and prevention. He draws on case studies of Prader-Willi, fragile X, DiGeorge, and velo-cardio-facial syndromes to illustrate that almost all testing in medical genetics is inseparable from the larger—and increasingly “big data”–oriented—aims of biomedical research. Hogan also reveals how contemporary genetic testing infrastructure reflects an intense collaboration among cytogeneticists, molecular biologists, and doctors specializing in human malformation. 
 
Hogan critiques the modern ideology of genetic prevention, which suggests all pregnancies are at risk for genetic disease and should be subject to extensive genomic screening. He examines the dilemmas and ethics of the use of prenatal diagnostic information in an era when medical geneticists and biotechnology companies offer whole genome prenatal screening—essentially searching for any disease-causing mutation. Hogan’s analysis is animated by ongoing scientific and scholarly debates about the extent to which the preventive focus in contemporary medical genetics resembles the aims of earlier eugenicists. Written for historians, sociologists, and anthropologists of science and medicine, as well as bioethics scholars, physicians, geneticists, and families affected by genetic conditions, Life Histories of Genetic Disease is a profound exploration of the scientific culture surrounding malformation and mutation.
Available since: 10/30/2016.
Print length: 280 pages.

Other books that might interest you

  • On the Backs of Tortoises - Darwin the Galapagos and the Fate of an Evolutionary Eden - cover

    On the Backs of Tortoises -...

    Elizabeth Hennessy

    • 0
    • 0
    • 0
    An insightful exploration of the iconic Galápagos tortoises, and how their fate is inextricably linked to our own in a rapidly changing worldThe Galápagos archipelago is often viewed as a last foothold of pristine nature. For sixty years, conservationists have worked to restore this evolutionary Eden after centuries of exploitation at the hands of pirates, whalers, and island settlers. This book tells the story of the islands’ namesakes—the giant tortoises—as coveted food sources, objects of natural history, and famous icons of conservation and tourism. By doing so, it brings into stark relief the paradoxical, and impossible, goal of conserving species by trying to restore a past state of prehistoric evolution. The tortoises, Elizabeth Hennessy demonstrates, are not prehistoric, but rather microcosms whose stories show how deeply human and nonhuman life are entangled. In a world where evolution is thoroughly shaped by global history, Hennessy puts forward a vision for conservation based on reckoning with the past, rather than trying to erase it.
    Show book
  • Waking Up in Eden - In Pursuit of an Impassioned Life on an Imperiled Island - cover

    Waking Up in Eden - In Pursuit...

    Lucinda Fleeson

    • 0
    • 0
    • 0
    A woman journeys to Kauai to save Hawaii’s native plants: “Part history, part personal confession, part cautionary tale about environmental preservation” (Gioia Diliberto, author of Paris Without End).   One day, Lucinda Fleeson quit her big-city newspaper job, sold her suburban house, and moved halfway across the world to the island of Kauai to work at the National Tropical Botanical Garden.   Imagine a hundred-acre garden estate nestled amid ocean cliffs, rain forests, and secluded coves. Exotic and beautiful, yes, but as Fleeson awakens to this sensual world, exploring the island’s food, beaches, and history, she encounters an endangered paradise—the Hawaii not shown in the tourist brochures.   Native plants are dying at an astonishing rate—Hawaii is called the Extinction Capital of the World—and invasive species (plants, animals, and humans) have imperiled this Garden of Eden. Fleeson accompanies a plant hunter into the rain forest to find the last of a dying species, descends into limestone caves with a paleontologist who deconstructs island history through fossil life, and shadows a botanical pioneer who propagates rare seeds, hoping to reclaim the landscape. Her grown-up adventure is a reminder of the value of choosing passion over security, individuality over convention, and the pressing need to protect the earth. And as she witnesses the island’s plant renewal efforts, she sees her own life blossom again.   “[An] impeccably researched, beautifully told tale of how America’s most exotic locale transformed the life of an urban journalist.” —Gioia Diliberto   “As she delves deep into the island’s history and ventures far into its delicate ecosystem, Fleeson undertakes her own personal and professional salvation, a spirited and daring pilgrimage that is both revelatory and enlightening.” —Booklist
    Show book
  • Restless Devices - Recovering Personhood Presence and Place in the Digital Age - cover

    Restless Devices - Recovering...

    Felicia Wu Song

    • 0
    • 0
    • 0
    We're being formed by our devices. Today's digital technologies are designed to captivate our attention and encroach on our boundaries, shaping how we relate to time and space, to ourselves and others, even to God. While we enjoy the benefits of digital tech, many of us feel troubled with its power and exhausted by its demands for permanent connectivity. Yet even as we grow disenchanted, attempting to resist the digital "powers that be" might seem like a losing battle.Sociologist Felicia Wu Song has spent years considering the personal and collective dynamics of living in digital ecosystems. In this book she combines psychological, neurological, and sociological insights with theological reflection to explore two major questions: What kind of people are we becoming with personal technologies in hand? and who do we really want to be?Song unpacks the soft tyranny of the digital age, including the values embedded in our apps and the economic systems that drive our habits and their subtle yet pervasive effects. She then explores pathways of meaningful resistance that can be found in Christian tradition, especially counter-narratives about human worth, embodiment, relationality, and time. Considering digital practices through the lens of "liturgy" and formation, she offers practical experiments for individual and communal change.
    Show book
  • Apollo 8 - The Thrilling Story of the First Mission to the Moon - cover

    Apollo 8 - The Thrilling Story...

    Jeffrey Kluger

    • 0
    • 0
    • 0
    The untold story of the historic voyage to the moon that closed out one of our blackest, bloodiest years with a nearly unimaginable triumphIn August 1968, NASA made a bold decision: in just sixteen weeks, the United States would launch humankind’s first flight to the moon. Only the year before, three astronauts had burned to death in their spacecraft, and since then the Apollo program had suffered one setback after another. Meanwhile, the Russians were winning the space race, the Cold War was getting hotter by the month, and President Kennedy’s promise to put a man on the moon by the end of the decade seemed sure to be broken. But when Frank Borman, Jim Lovell and Bill Anders were summoned to a secret meeting and told of the dangerous mission, they instantly signed on.Written with all the color and verve of the best narrative non-fiction, Apollo 8 takes us from Mission Control to the astronaut’s homes, from the test labs to the launch pad. The race to prepare an untested rocket for an unprecedented journey paves the way for the hair-raising trip to the moon. Then, on Christmas Day, a nation that has suffered a horrendous year of assassinations and war is heartened by an inspiring message from the trio of astronauts in lunar orbit. And when the mission is over—after the first view of the far side of the moon, the first earth-rise, and the first re-entry through the earth’s atmosphere following a flight to deep space—the impossible dream of walking on the moon suddenly seems within reach. The full story of Apollo 8 has never been told, and only Jeffrey Kluger—Jim Lovell’s co-author on their bestselling book about Apollo 13—can do it justice. Here is the tale of a mission that was both a calculated risk and a wild crapshoot, a stirring account of how three American heroes forever changed our view of the home planet.
    Show book
  • Summary of Sean Cannell & Benji Travis's Youtube Secrets - cover

    Summary of Sean Cannell & Benji...

    Falcon Press

    • 0
    • 0
    • 0
    Buy now to get the main key ideas from Sean Cannell & Benji Travis's Youtube Secrets 
      
    In YouTube Secrets (2018), Benji Travis and Sean Cannell explain how to build a YouTube channel and become an influencer. They base their advice on their personal experience on the platform as well as the stories of other creators including Gary Vaynerchuk, Casey Neistat, Melanie Ham, and many others. Travis and Cannell guide aspiring YouTube creators through the tough first steps of building a channel and set them on the path to success.
    Show book
  • Rapid Weight Loss Hypnosis - Hypnotherapy: a New and Easy Way to Stop Sugar Cravings Compulsive Overeating & Emotional Eating Find the Right Motivation for the Natural Slim Body you Deserve - cover

    Rapid Weight Loss Hypnosis -...

    Berry Keys

    • 0
    • 0
    • 0
    Lose Weight, Stop Emotional Eating and Free Yourself From Cravings With Hypnotherapy!  
    Have you tried numerous diets and exercise plans, but you’re not losing enough or any weight? 
    Have you had enough of trying out restrictive diets, which make you cranky, depressed and tired? 
    Do you overeat when struggling with certain life situations or emotions? 
    This might come as a shock to you, but there is a way you can lose weight, boost your metabolism and get rid of bad habits without dieting and exercising. It might sound like utopia, but it’s real and it’s called hypnotherapy. Hypnosis will cure you of that subtle, yet dangerous little monster called craving. It is responsible for at least a few of those extra pounds on your body. Cravings happen in our minds, not our bodies. They are a completely psychological disease, and hypnosis is a cure. In this incredibly detailed guide on the power of hypnotherapy, you’ll find out how to effectively lose weight, get rid of bad eating habits and disorders and feel and look better then ever before!  
    Here’s what you get with this book: A guide on different types of hypnotherapy and recommendations for what to look for in hypnotherapistsHow hypnotherapy treats eating disordersHypnosis techniques that will help you lose weight and stop the craving!Methods for getting rid of sugar addiction and emotional eatingAnd much more! 
    Join the exclusive club of hypnotherapy enthusiast, and solve your weight problems in a flash!Get Your Copy Now!
    Show book